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Here we defined a signature of 59 genes and two metabolites (GSH and NADP) that is robustly associated with NRF2 dependency across an extensive panel of cancer cell lines

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This pathway signals through Gq-phospholipase C-IP3 cascades, increasing intracellular calcium and promoting GH vesicle exocytosis

In a phase 2 dose-finding trial in adults with obesity or overweight, survodutide produced dose-dependent reductions in body weight and was described as a glucagon receptorGLP-1 receptor dual agonist

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