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Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints

While a negative feedback loop has not been identified, the very high levels of these medications not only flood the body, but do so for extended periods, unlike endogenous GLP-1, which normally fluctuates in response to eating

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This may cause various skin issues, including hyperpigmentation

So, using Fiber Supplements can be a good way to stimulate peptide hormones in our gut

2020 Jan 2;12(1)