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In conclusion, all our findings revealed that semaglutide or calorie restriction exhibited protective effects against HFD-induced -cell dysfunction by regulating METTL3/14, PDX-1, and insulin signaling, showed beneficial effects on reducing the lesion on the obese mice islet

The results also support that Esm1 + cells and arterial ECs are derived from Aplnr + ECs

It helps protect cells from oxidative stress while supporting healthy skin appearance, hydration, and glow

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