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Semaglutide activates GLP-1 receptors alone, while tirzepatide activates both GLP-1 and GIP receptors, often producing faster or greater weight loss (up to 22% in trials)
This stack is popular in Chicago among people who are lifting regularly or pursuing recomposition, losing fat while maintaining or gaining lean mass, especially those who also struggle with fragmented sleep from work stress or latenight schedules
For more on what to expect over time, the guide on semaglutide results week by week tracks the full progression of changes
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It also causes temporary (3 months) paralysis of the muscle being innervated by those nerve endings