Not all metabolic surgeries are the same
That simplicity is also what keeps costs down
GLP-1 medications slow digestion, which may impair B12 absorption
The MASH mouse and hamster work published by Briand and colleagues in 2026 showed dose-dependent reductions in body weight, hepatic steatosis, and liver enzymes that exceeded what dual agonists produced in the same models (Briand et al., Obesity, 2026)
Additionally, legal and regulatory considerations vary by region, necessitating awareness before considering MK-677
Each protocol outlines the study rationale and design following the HARmonized Protocol Template to Enhance Reproducibility (HARPER), a structured framework for transparent and reproducible observational study design 44