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Evidence from in vitro, animal, and small human studies indicates low toxicity

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[91] Since only bacteria and some archea possess the genes and enzymes necessary to synthesize vitamin B 12 , plant and algae sources all obtain the vitamin secondarily from symbiosis with various species of bacteria, [5] or in the case of fermented plant foods, from bacterial fermentation

They often feel like a "skipped beat" followed by a strong, noticeable thump