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Ferroptosis is mediated by multiple mechanisms including lipid peroxidation, iron overload and dysfunction of the antioxidant system (Fig

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18,23,123 The prototypical example of a genetic primary astrocytopathy is Alexander disease, a leukomalacia in which astrocytes express mutant GFAP, although how the expression of this mutant gene translates into severe damage of the white matter remains unknown

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