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The interaction between vitamin B12 and Apolipoprotein E (APOE) significantly influences cognitive function in older adults, with APOE carriers showing a stronger positive association between vitamin B12 levels and cognitive performance compared to noncarriers [61]
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The trial enrolled 17,604 adults and has been conducted in 41 countries at more than 800 investigator sites
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CRISPR/Cas9 generation of ADH5 and GCLM cell lines HCT116 ADH5 , GCLM , TP53 ADH5 , and ADH5 GCLM cell lines were generated by targeting exon 3 of ADH5 (sgRNA: TGCTGGAATTGTGAAAGTGTT) and exon 1 of GCLM (sgRNA: ACGGGGAACCTGCTGAACTG) in the corresponding parental cell lines
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