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Both the Sema and the Sema + -MSTN/-ActA groups showed significant and similar reductions in body weight compared to the control group over the 28-day treatment period

Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists

Therefore, further investigation into the role of NRF2 in psoriasis and the exploration of safe and effective NRF2 activators for psoriasis treatment are warranted