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Interestingly, most of the differentially expressed CSEPs were represented in only four clusters (clusters 1, 4, 5 and 7), all of which show peak expression in the mid and/or late stages of disease development ( Figure 4 )

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Treatment with GLP-1RAs can regulate several pivotal miRNAs (such as miR-93-5p, miR-181a-5p and miR-34a-5p and miR-26a-5p) to inhibit apoptosis in endothelium [116]

Begin with reduced frequency and gradually increase based on skin comfort

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