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(R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling

In the COR-II trial, participants lost about 6.4% of body weight at 56 weeks

Meet defined BMI clinical criteria: Body Mass Index (BMI) 35

doi: 10.1159/000369670 90 NakamuraYNakayaHSaitoNWakitaniS

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The lower limit of PRR for the following HLT tumors was invariably greater than 1 in five models: thyroid neoplasms benign and malignant, pancreatic neoplasms malignant (excl islet cell and carcinoid), and islet cell neoplasms and APUDoma NEC (ICN&AN)