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They are complementary and even support each other to functionthink of them as two very different players on the same team

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SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)

EEG recordings conducted during wakeful and sleep periods at 6 months of age showed paroxysmal multispike and slow-wave activity in the right parietooccipital region, along with monorhythmic activity at a frequency of about 8 Hz in the left parietooccipital region