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They were testing the theory that mitochondrial decline is caused by free radical damage (see panel opposite)

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The use of potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated (see WARNINGS: CYP 3A4 Inhibitors)

Acta Neuropathol Commun 2015;3:31

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