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Strober W, Asano N, Fuss I et al (2014) Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohns disease

The peptide has been the subject of multiple in vitro and animal studies (and a smaller number of human observational studies) published in Bulletin of Experimental Biology and Medicine , Biogerontology , and other journals

AOD-9604 is a synthetic peptide fragment (amino acids 176-191 of human growth hormone) that stimulates fat breakdown through beta-3 adrenergic receptors in adipose tissue, working peripherally on fat cells rather than centrally on hunger signals

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By preventing NFB from entering the cell nucleus, it reduces production of proinflammatory signals including TNF, IL1, IL6, and IL12