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Physiology 78 (1), 277299

Additionally, Martin et al

found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

Moreover, BPC 157 exhibits cytoprotective properties, meaning it can shield cells from damage induced by harmful agents such as toxins or oxidative stress

As key metabolic products of gut symbiotic microorganisms (such as Bacteroides and Lactobacillus), SCFAs not only help maintain the integrity of the intestinal mucosal barrier but also effectively suppress intestinal inflammation