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Ann Agric Environ Med 30(3):513521

These findings align with literature proposing multiple pathways through which semaglutide may act, mitigating vascular stiffening, adverse lipid profiles, inflammation, and endothelial dysfunction, alongside effects on glycemic control, insulin resistance, and weight loss [1, 4]

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Cordiner RLM, Mari A, Tura A, et al

Dehydration can cause further complications such as low blood pressure, electrolyte imbalance, and acute kidney injury

This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)