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[PubMed] Gaiday AN, Tussupkaliyev ABT, Bermagambetova SK, et al.Effect of homocysteine on pregnancy: A systematic review

Nutrients, 2 (3), 299316

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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired