Psoriasis has increasingly been linked to metabolic disorders such as diabetes, obesity, and dyslipidemia [199, 200]
Bivamelagon Bivamelagon (formerly LB54640) is an oral MC4R-selective small molecule agonist as shown in Figure 2 , with nanomolar potency on hMC1R (EC 50 = 84.82 nM) and hMC3R (EC 50 = 130 nM) and low nanomolar potency on hMC4R (EC 50 = 0.98-16.28 nM) ( Table 1 ) (98)
The strategic intent is clear: to offer ingredient solutions that meet the rising consumer demand for functional with proof, while giving brands new tools to differentiate in a crowded wellness landscape
Engage with digital health tools - like CGM and insulin delivery systems that enhance control and reduce daily burden
For someone on tirzepatide who is adjusting their diet and increasing physical activity, these effects could meaningfully improve body composition outcomes
A few common ones include reducing your cardiovascular risk, maintaining a healthy weight, and controlling your blood sugar