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Mice were subcutaneously injected with either vehicle (5% DMSO/95% 40 mM Tris pH 8.0) or tirzepatide (dose ranging from 1-30 nmol/kg in pilot dose-finding study, 3-10 nmol/kg in tumor studies in male mice, 3-30 nmol/kg in female mice, and 3-75 nmol/kg in female mice housed at thermoneutrality

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The clinical adoption of GLP-1 receptor agonists has outpaced manufacturing, leading to significant supply chain challenges that impact accessibility (Garvey, Diabetes, Obesity and Metabolism )

Attenuation of DIO in PAR2-G37I mice was associated with significantly reduced numbers of total CD11b + and CD11b + CD11c + ATMs within the SVF with a reciprocal increase in CD11b CD11c and unchanged CD11b CD11c + cells (Supplemental Figure 5H)

To get more complete and reliable data, Novo Nordisk has since launched a new phase 3 program called RENEW

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