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Trends Immunol 2018;39:489502

doi: 10.1016/j.nano.2016.05.021

DHEA (Dehydropiandrosterone): DHEA is a hormone secreted by the adrenal glands and in smaller amounts by the ovaries and testes

Moreover, injectable systems can be designed to respond dynamically to the local microenvironmentsuch as pH, temperature, or enzymatic activityallowing on-demand modulation of therapeutic release in direct synchrony with brachytherapy dosing [142, 143]

The name for the method of injecting into the belly (abdomen) area is subcutaneous injection

Tumor risk via p53 pathway interference Mitigate risk by: Careful patient selection: exclude patients with pre-existing active malignancy or high tumour risk (e.g., known p53 mutations, familial cancer syndromes)