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Sample collection The samples were processed under standardized conditions with support from the IRBLleida Biobank (B0.000682) and the Biobank and Biomodels Platform ISCIII PT23/00032

The inbred Lewis-F344 rat kidney transplant models were used for a 14-weeks observation and subsequent mechanistic investigations, while the outbred SD-Wistar rat kidney transplant models were used for a 26-weeks survival analysis