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Bottom line: While splitting a dose might physically be possible with vials, the lack of clinical data and the increased risk of infection or dosing errors make it a risky choice without professional medical oversight

A 2025 meta-analysis of randomised controlled trials found no signal

High-fiber foods, certain carbohydrates (especially refined sugars and sugar alcohols), and large meal volumes all ferment more readily in your colon when gastric emptying is slowed

Medicine 102 , E32586 (2023)

Pfizer, the manufacturer of Depo-Provera, is the primary party being sued in these lawsuits