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Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/- mice but does not reduce atherosclerosis

These findings were supported by the relaxation of large vessels (ex vivo), mainly by acting on vascular endothelial cells but also on vascular smooth muscle cells, increasing NO production and migration of endothelial cells, activating the signal pathways of Src, Cav-1, and eNOS, and reducing proteinprotein interaction between eNOS and Cav-1 [121,122]

The peptide appears particularly effective for surgical wounds , chronic ulcers , and traumatic injuries where normal healing processes may be impaired

Interventions using specific dietary components and engineered probiotics show promise in restoring gut-liver homeostasis and mitigating cadmium-induced damage

doi: 10.1016/j.ijbiomac.2025.143989 127 ZhangHLiuXZhengYZhaXElsabaghMZhangYet al