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GLP-1 737 and GLP-1 736 amide are essentially equipotent at the GLP-1R [9] and although present at approximately equivalent concentrations in plasma during fasting, the amidated version is the major circulating form post-prandially [10]

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Small peptides such as exenatide and lixisenatide get into the central nervous system at measurable levels, whereas larger or chemically modified analogues such as liraglutide and semaglutide barely get in under normal conditions

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For the colitis score, the weight loss rate, stool hardness, and anal bleeding were quantified as shown in Table 1

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