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Pycnogenol was resulted in reduced hyperpigmentation in melasma patients after 1 month of systemic therapy (Sarkar et al., 2012b
The first comes from the blood, where DNA methylation clocks such as Systems Age from TruDiagnostics, Proteomics-based aging clocks like those from Vero, and RNA signatures read the activity of brain specific aging-associated genes, which is the basis of the NeuroAge panel
Secondly, vascular function and tone also demonstrate robust core clock rhythms, best characterized through blood pressure peaks which are observed prior to the onset of the active cycle (light phase in diurnal species) followed by mid-morning peaks and decreases during the evening (inactive phase) (Millar-Craig et al., 1978)
The combination is designed to be taken together for synergistic effects
With regards to the horse, additional research is critically needed and should use models of both healthy horses and those suffering from gastrointestinal disease
