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65,66 By forcing proximity between the target and ligase, PROTACs induce polyubiquitination and proteasomal degradation

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Indeed, GSTP1 expression can predict pathological response to chemotherapeutic treatments with 5-fluorouracil/epirubicin/cyclophosphamide in ER-negative tumors but not in ER-positive tumors

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Weight loss of approximately 25% was maintained for up to ten years post-surgery