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A 6-week phase 1 study of participants without T2D who had overweight or obesity found reduced activation (estimated from blood oxygen level dependent signal functional MRI) in certain brain regions relevant to appetite regulation in response to high-fat/high-sugar food images among participants assigned to tirzepatide 10 mg as compared with placebo [75]

The Multiple Risk Factor Intervention Trial (MRFIT)importance then and now

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Coverage is the quiet variable Whether any of this matters depends on coverage, which depends on the FDA-approved indication and your plan's formulary

With the current public attention given to the dramatic weight loss achieved with these weight loss medications, patients are seeking them out from many potential sources, including online prescribers