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Charles Brenner, who discovered nicotinamide riboside as an NAD+ precursor, conducted a 2016 clinical trial showing oral NR supplementation safely increased human blood NAD+ levels up to 2.7-fold [14]

They exhibit diverse pharmacological activities, including anti-inflammatory, antioxidant, antitumor, and neuroprotective effects, making them highly valuable in medicine

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The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial

Similar studies have been performed in various other groups, including obese patients