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Based on the naranjo adverse drug reaction probability scale and the WHO-Uppsala Monitoring Centre (WHO-UMC) causality assessment system, the association between tirzepatide and rhabdomyolysis was classified as probable. To our knowledge, no previous cases of tirzepatide-induced rhabdomyolysis for T2DM have been reported in the literature

Demeestere I, Gervy C, Centner J, Devreker F, Englert Y, Delbaere A: Effect of insulin-like growth factor-I during preantral follicular culture on steroidogenesis, in vitro oocyte maturation, and embryo development in mice

These findings align with evidence that GLP-1 is widely expressed and secreted within the nervous system, supporting potential effects in either the central or peripheral nervous system, the researchers wrote

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For experiments comparing more than two groups, one-way ANOVA and two-way ANOVA were used