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Depletion of intracellular GSH appears to be critical for subsequent alterations in protein thiol and calcium homeostasis

Importantly, bortezomib has shown promise in refractory SLE patients, 540,541 emphasizing the translational relevance of proteasome modulation in severe autoimmune disease

Mechanisms of Action: The Core Difference This is where the two compounds genuinely diverge

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Because these databases contain many cases of polypharmacy, there may be confounding factors that affect the occurrence of drug-induced symptoms

While serological markers such as anti-dsDNA and anti-Smith antibodies are commonly used, they lack sensitivity and specificity across all disease stages and patient populations