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Eight studies had low risk of bias (5557, 61, 64, 71, 72), 11 studies had moderate risk of bias (50, 54, 58, 63, 65, 68, 74, 75, 79) and 22 studies had high risk of bias (5153, 59, 60, 62, 66, 67, 69, 70, 73, 7678, 80)

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Moreover, it plays an important role in glutamate neurotransmitter metabolism and neural regulation [20]

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