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Yes intranasal dihexa produces a systemic plasma half life of one to two hours (similar to intraperitoneal), but CNS tissue half life is extended to four to six hours because the peptide is transported directly to the brain along olfactory and trigeminal nerve pathways, bypassing blood-brain barrier penetration and hepatic first-pass metabolism

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For example, insulin and growth hormone are peptide-based hormones because they are made from amino acid chains

9.2 Atopic dermatitis An atopic dermatitis CD48/80-induced itch murine model treated with apigenin (75, 150 mg/kg) saw reduced the number of scratches and inhibited the infiltration of polymorphonuclear lymphocytes [134]

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