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The decision was controversial, and on remand the case produced mixed results, but the practical effect has been to make skinny labeling a higher-stakes strategy for generic manufacturers

Patients often face potentially high costs even with partial coverage for the branded semaglutide versions

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Sustained TNF- signaling may also impair microglial clearance of A, reinforcing a self-perpetuating inflammatory cycle

However, the full effect of the treatment typically takes around 16-20 weeks to be fully realized, with patients often losing 10-15% of their body weight by the 6-month mark, depending on factors like diet, exercise, and overall adherence to the treatment plan

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