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Lysosomal signaling promotes longevity through adjusting mitochondrial activity graphical abstract

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To investigate the importance of sAC in GLP-1(2836)stimulated cAMP generation in human caECs, we also blocked the anion (HCO 3 ) entry required for sAC activity using probenecid (39)

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Furthermore, emerging strategies, such as acetazolamide combined with remote ischemic preconditioning (RIPC), have shown additional risk reductions under controlled hypoxia exposure