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In the kidney, GLP-1 receptors are predominantly expressed on vascular smooth muscle cells of the afferent arteriole [63]

On the other hand, when injected into the body, specifically in the abdomen, GLP-1 can remain effective for up to 24 hours without being destroyed by the enzyme, allowing it to work continuously to suppress appetite and aid in weight loss

Others feel nothing different at all

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Starting at a higher dose skips the critical adaptation period for the GLP-1, GIP, and glucagon receptors and almost always produces severe gastrointestinal side effects