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If you don't see adequate results after reaching the target dose and giving the medication sufficient time (typically 12 to 16 weeks at the maintenance dose), your provider may recommend switching to a different GLP-1 medication, adjusting your dose, or adding other interventions

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The animals were then deeply anesthetized with 3% isoflurane and 50 mg/kg of ketamine followed by a laminectomy at lumbar level L2-L3, corresponding to the sacrocaudal spinal cord