Overall, the trials found that a lower starting dose (2 mg) during the dose increasing phase could help reduce the frequency and severity of GI side effects, compared to a higher initial dose (4 mg)
4,5 In the retina, pre-clinical studies have revealed potentially anti-inflammatory and neuroprotective effects independent of glucose-lowering effects
The Phase 3 TRIUMPH trials use a similar protocol
Because of the high unit price and total expense of these medications, countries are now deliberating on whether and how to cover them as treatments for obesity [64]
Evaluation and management of adult hypoglycemic disorders: An endocrine society clinical practice guideline
Since January 2026, there have been six cases of acute liver injury in Victoria in people who have used an unapproved peptide product, labelled as Retatrutide