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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46
Marisa Garshick, a dermatologist based in New York City
Annu Rev Nutr 27:241261 Brggemann C, Denger K, Cook AM et al (2004) Enzymes and genes of taurine and isethionate dissimilation in Paracoccus denitrificans
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(73) reported that in hepatocytes, L-carnitine inhibited stress-induced transcription factor early growth response protein 1 (EGR1), subsequently downregulating its target gene NEDD9 and modulating the NEDD9/FAK/AKT pathway, signaling pathway, indicating a potential protective mechanism in that experimental context