Code availability The source code used to analyze the bulk RNA-seq data is available at Change history 30 October 2025 The original online version of this article was revised: In the originally published version of this article, Figure 4 contained an error in the RNA-seq analysis
Phase 2 trials published in the New England Journal of Medicine showed the 12 mg dose group losing 24.2% of body weight at 48 weeks
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If you experience any of these, contact your healthcare provider immediately
Many of these trials do not adhere to the standards required for high-quality clinical research, such as adequate blinding and randomization, further diminishing their credibility
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