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Previously, a two-compartment pharmacokinetic (PK) model was used to describe semaglutide absorption, distribution and elimination, using data from nine clinical pharmacology trials, eight of which involved once-weekly s.c

Jolkkonen et al., 1986

For a deeper look at what GLP-1 approval actually required, Meto's clinical overview of GLP-1 drugs provides useful context as does our recent piece on Foundayo (orforglipron), the first oral GLP-1 to reach approval

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