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GLP-1 RA initiators also had a lower risk for initiation of tricyclic antidepressants (RR, 0.65), valproate (RR, 0.52), gepants (RR, 0.77), calcitonin gene-related peptide monoclonal antibodies (RR, 0.58), and serotonin-norepinephrine reuptake inhibitors (RR, 0.80)

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Hasanov M, Acikgoz Y, Davies MA

Most of the foundational studies are animal models, with a growing body of clinical observation and anecdotal reporting from practitioners and patients