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May 11, 2025

82.0% of the patients were being treated with metformin HCl, 40.9% with insulin, 42.7% with a sulfonylurea, 16.8% with a DPP4 inhibitor, and 4.4% with a GLP-1 receptor agonist

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Documented research endpoints include receptor binding and selectivity profiling, comparative pharmacology alongside single- and dual-agonist compounds, metabolic signaling pathway analysis, insulin secretion and glucose metabolism assays, and energy homeostasis modeling

More variables means more careful titration