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Yes, indirectly

Biosynthesis of S -alk(en)yl-L-cysteine sulfoxides is initiated by S -alk(en)ylation of glutathione, which is followed by the removal of glycyl and -glutamyl groups and S -oxygenation

High B12 is not usually dangerous on its own, but may point to issues like liver disease, kidney dysfunction, or blood cancers

Given that it works so well for some people, and it is rather inexpensive, I would definitely recommend people try it

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings

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