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For instance, butyrate promotes an anti-inflammatory response through the differentiation of Treg cells as well as through the stimulation of nuclear transcription factor, peroxisome proliferator-activated receptor gamma (PPAR-y) which lead to the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway and of the activity of histone deacetylases (HDACs)

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Autoimmunity Reviews , 8 (8), 697701

When this conversion is impaired due to reduced methylfolate, homocysteine accumulates in the blood, causing inflammation and oxidative stress in blood vessels