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Research Insight: The SURMOUNT-5 trial, a phase 3b study, demonstrated that participants treated with tirzepatide experienced a superior percentage change in body weight and waist circumference compared to those treated with semaglutide over 72 weeks

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Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE et al (2020) Age-related shift in LTD is dependent on neuronal adenosine A 2A receptors interplay with mGluR5 and NMDA receptors