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This novel MNM does not rely on drug loading but uses the receptor structures on the biofilm surface to target aggregated cells for therapeutic effects

Subcutaneous administration introduces variability that intravenous routes avoid

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Additional regulatory mechanisms include SRC-2mediated reductive carboxylation, compensatory glutamine addiction induced by PDHA1 loss, Guanine Monophosphate Synthetase(GMPS) driven purine biosynthesis, reciprocal regulation between GLS and CAD, epigenetic modulation via MeCP2/DNMT, and C5a complement signaling that promotes glutamine consumption in castration-resistant prostate cancer (4143)