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Intracerebroventricular and intravenous administration of synthetic DSIP in rabbits and rats has been reported to increase the proportion of EEG delta activity and slow-wave sleep without consistently suppressing REM (paradoxical) sleep (Schoenenberger & Monnier, 1977

This mimics normal physiology and avoids disrupting hormone feedback loops

These options differ primarily in delivery format, access requirements, documentation transparency, and regulatory considerations

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Scientific Reports, 10 (1), 1-11

PMCID: PMC5794882