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1 The growth of melanoma can be described as follows: In situ : the tumour is confined to the epidermis Invasive : the tumour has spread into the dermis Metastatic : the tumour has spread to other tissues When melanocytes grow in a non-cancerous way, they result in moles (benign melanocytic naevi) and freckles (lentigines and ephelides)

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Administer the following dose by deep intramuscular, sub-cutaneous or slow intravenous injection

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Needle length: The listed needle length, such as 5/16 inch or 1/2 inch

Pharmacologically, melatonins appeal lies in its wide therapeutic index, high safety profile, and low toxicity even at high doses