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However, topline results released by NovoNordisk stated that their two phase 3 trials investigating once-daily oral semaglutide in early-stage Alzheimers disease (clinical trial numbers NCT04777396 and NCT04777409) did not confirm the superiority of semaglutide versus placebo in reducing the progression of Alzheimers disease, as measured by the change in Clinical Dementia Rating Sum of Boxes score compared with baseline

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This precautionary approach stems from theoretical concerns that elevated GH and IGF-1 could potentially accelerate existing malignant cell growth, particularly in breast, prostate, or colorectal tissues