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Inhibition of these non-oxidative pathwaysincluding glycolysis, the PPP, and HIF/mTORC1 signalingconsistently reduces viral replication, whereas interventions that enhance glycolysis or suppress mitochondrial activity worsen disease ( Beyond the acute phase of infection, mitochondrial dysfunction persists across multiple tissues

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Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit

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Indian J Microbiol 60:405419 Wachsmuth HR, Weninger SN, Duca FA (2022) Role of the gutbrain axis in energy and glucose metabolism